Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.65 |
| ▸ | HTR2C | P28335 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | HRH1 | P35367 | 3/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.65 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21245399 | 0.95 | SLC6A4 (0.59) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| SCHEMBL13051501 | 0.79 | HTR2A (0.78) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL34384 | 0.79 | SLC6A4 (1.00) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL29379525 | 0.79 | SLC6A4 (1.00) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL5072939 | 0.79 | SLC6A4 (1.00) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL28110431 | 0.79 | SLC6A4 (0.78) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| SCHEMBL1799258 | 0.78 | HTR2A (0.56) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| SCHEMBL13808474 | 0.78 | SLC6A4 (0.69) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL27517227 | 0.78 | SLC6A4 (0.83) | SLC6A4SLC6A2HTR2ACHRM1DRD2 | |
| Desipramine SCHEMBL5501781 | 0.78 | SLC6A2 (1.00) | SLC6A4SLC6A2HTR2ACHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | claimed |
| EP-1838690-A2 | COMPOUNDS WITH KV4 ION CHANNEL ACTIVITY | Devgen N.V. (BE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006066879-A2 | COMPOUNDS WITH KV4 ION CHANNEL ACTIVITY | DEVGEN N.V. (BE) | 2006-06-29 | — | — | WO | claimed |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | KCNA4, HCN4, KCNN4 | SLC6A4 150/4885SLC6A2 329/4885HTR2A 2253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.