Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | UGCG | Q16739 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916106 | 0.96 | NPY1R (0.42) | NPY1RNPY5RUGCGADORA2AADORA1 | |
| SCHEMBL2657321 | 0.92 | NPY1R (0.40) | NPY1RNPY5RUGCGGABRG2GABRB3 | |
| SCHEMBL2660844 | 0.91 | NPY1R (0.41) | NPY1RNPY5RUGCGADORA2AGABRG2 | |
| SCHEMBL2661489 | 0.91 | NPY1R (0.40) | NPY1RNPY5RUGCGGABRG2GABRB3 | |
| SCHEMBL2662058 | 0.90 | GABRG2 (0.44) | NPY1RNPY5RUGCGGABRG2GABRB3 | |
| SCHEMBL2669426 | 0.90 | NPY1R (0.40) | NPY1RNPY5RADORA2AGABRG2GABRB3 | |
| SCHEMBL2661576 | 0.89 | CRHR1 (0.41) | NPY1RNPY5RGABRG2GABRB3GABRA2 | |
| SCHEMBL4912799 | 0.89 | GABRG2 (0.49) | NPY1RNPY5RGABRG2GABRB3GABRA2 | |
| SCHEMBL2662080 | 0.89 | GABRG2 (0.43) | NPY1RNPY5RUGCGGABRG2GABRB3 | |
| SCHEMBL2661253 | 0.89 | NPY1R (0.40) | NPY1RNPY5RGABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | claimed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | NPY1R 126/4885NPY5R 104/4885UGCG 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.