Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 11/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 10/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916205 | 0.81 | CYP17A1 (0.44) | HSD17B2HSD17B1ERCC5FEN1CTSC | |
| SCHEMBL4916202 | 0.81 | CYP17A1 (0.44) | HSD17B2HSD17B1ERCC5FEN1CTSC | |
| SCHEMBL6031891 | 0.76 | DGAT1 (0.51) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1748196 | 0.76 | DGAT1 (0.51) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1748016 | 0.76 | DGAT1 (0.51) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4923255 | 0.75 | HSD17B1 (0.39) | HSD17B2HSD17B1ERCC5FEN1HDAC1 | |
| SCHEMBL4920884 | 0.72 | PDE4A (0.41) | HSD17B2HSD17B1FEN1 | |
| SCHEMBL4920876 | 0.72 | PDE4A (0.41) | HSD17B2HSD17B1FEN1 | |
| SCHEMBL4922146 | 0.70 | HPGD (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL4922141 | 0.70 | HPGD (0.47) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064717-A1 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LABORATORIES | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064717-A1 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | DGAT1, DGAT2, DLAT | HSD17B2 1356/4885HSD17B1 486/4885ERCC5 4855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.