Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916445 | 0.97 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4913800 | 0.97 | LMNA (0.50) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4920736 | 0.92 | LMNA (0.52) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4916491 | 0.89 | MMP2 (0.53) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4923892 | 0.89 | LMNA (0.51) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4924918 | 0.89 | LMNA (0.51) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4913649 | 0.86 | MMP2 (0.52) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4922337 | 0.86 | MMP2 (0.52) | SMN1; SMN2LMNAALDH1A1MMP2MMP13 | |
| SCHEMBL4920802 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1POLBGAA | |
| SCHEMBL4922316 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | CCR1, CCR3, CCR2 | SMN1; SMN2 3688/4885LMNA 2533/4885ALDH1A1 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.