Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.60 |
| ▸ | ESRRG | P62508 | 1/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929284 | 0.88 | HDAC1 (0.58) | KMT2AHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4929271 | 0.85 | HPGD (0.57) | KMT2AHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4929281 | 0.85 | HDAC1 (0.57) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4927509 | 0.85 | HDAC1 (0.58) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4926122 | 0.84 | ROCK2 (0.58) | KMT2AHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4926151 | 0.83 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4930312 | 0.82 | ESRRG (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4927694 | 0.81 | RXFP1 (0.51) | KMT2AHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4924579 | 0.80 | HDAC3 (0.68) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4922596 | 0.80 | HPGD (0.64) | KMT2AHDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | claimed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1708697-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1708697-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005074642-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293716-A1 | Chemical Compounds | CYP11B2, CYP11B1, REN | KMT2A 4386/4885HDAC1 261/4885HDAC3 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.