Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | XBP1 | P17861 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 10/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923684 | 0.90 | LMNA (0.75) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4925538 | 0.90 | MAPT (0.72) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL6203816 | 0.84 | MAPT (0.68) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4925406 | 0.81 | LMNA (0.64) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4926128 | 0.79 | TP53 (0.79) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL6206486 | 0.77 | GSK3B (0.60) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL3875705 | 0.77 | XDH (0.74) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL839950 | 0.77 | SLC2A1 (0.60) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL14553047 | 0.77 | MAPT (0.64) | MAPTKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4924582 | 0.76 | TP53 (0.59) | MAPTKDM4EHSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096868-A1 | 1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors | NOVARTIS AG (CH) | 2008-04-24 | — | — | US | claimed |
| EP-1812441-A1 | 1,4 SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050946-A1 | 1,4 SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-05-18 | — | — | WO | claimed |
| US-20080096868-A1 | 1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors | NOVARTIS AG (CH) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096868-A1 | 1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors | MAP3K1, MAP4K2, MAP4K5 | MAPT 1638/4885KDM4E 855/4885HSD17B10 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.