Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.60 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.60 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338958 | 0.87 | GSK3B (0.57) | GSK3BSLC2A1SLC2A2SLC2A3MAPT | |
| SCHEMBL6205500 | 0.85 | XDH (0.71) | SLC2A1SLC2A2SLC2A3MAPTALDH1A1 | |
| SCHEMBL839950 | 0.84 | SLC2A1 (0.60) | GSK3BSLC2A1SLC2A2SLC2A3MAPT | |
| SCHEMBL3875705 | 0.84 | XDH (0.74) | GSK3BSLC2A1SLC2A2SLC2A3MAPT | |
| SCHEMBL8344009 | 0.84 | GSK3B (0.57) | GSK3BSLC2A1SLC2A2SLC2A3MAPT | |
| SCHEMBL6207703 | 0.81 | SLC2A1 (0.58) | GSK3BSLC2A1SLC2A2SLC2A3MAPT | |
| SCHEMBL6204755 | 0.81 | GSK3B (0.54) | GSK3BMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL6205850 | 0.81 | TP53 (0.62) | MAPTALDH1A1HSD17B10KDM4EMEN1 | |
| SCHEMBL6203816 | 0.81 | MAPT (0.68) | GSK3BMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL1353714 | 0.81 | TSHR (0.53) | GSK3BSLC2A1SLC2A2SLC2A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |