SCHEMBL4926575

SCHEMBL4926575

CC(C)Nc1cc(Cl)cc(COc2c(Cl)cc(CC(F)C(=O)O)cc2Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.39
LMNA P02545 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MAPT P10636 2/20 0.35
FFAR4 Q5NUL3 1/20 0.34
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
FNTA P49354 1/20 0.31
FNTB P49356 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
SLC7A5 Q01650 1/20 0.31
CFD P00746 1/20 0.31
F11 P03951 1/20 0.31
TPSB2 P20231 1/20 0.31
GLRA1 P23415 1/20 0.31
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4931005 0.90 FFAR1 (0.37) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL4922880 0.90 THRB (0.40) FFAR1FFAR4THRB
SCHEMBL4935426 0.90 FFAR1 (0.39) FFAR1MRGPRX4MEN1KMT2AFFAR4
SCHEMBL5112370 0.89 FFAR1 (0.39) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL4933397 0.89 FFAR1 (0.40) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL4931145 0.87 MME (0.40) FFAR1MRGPRX4FFAR4ALDH1A1THRB
SCHEMBL5116056 0.87 PTGER1 (0.38) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL4922903 0.87 FFAR1 (0.39) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL5110942 0.86 FFAR1 (0.37) FFAR1LMNAMRGPRX4MEN1KMT2A
SCHEMBL4933984 0.86 FFAR1 (0.39) FFAR1LMNAMRGPRX4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080221210-A1 Thyroid Receptor Agonists KARO BIO AB (SE) 2008-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080221210-A1 Thyroid Receptor Agonists TSHR, TRHR, THRA FFAR1 37/4885LMNA 3893/4885MRGPRX4 119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.