Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179397 | 0.66 | SMN1; SMN2 (0.43) | MEN1KMT2APRCPMAPTGAA | |
| SCHEMBL7809939 | 0.65 | DRD2 (0.37) | MEN1KMT2AMAPTGAACA1 | |
| Hydrochloric Acid SCHEMBL8743281 | 0.65 | PRCP (0.40) | MEN1KMT2APRCPNPC1MAPT | |
| SCHEMBL14247747 | 0.64 | BCL2L1 (0.38) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL5771626 | 0.63 | CREBBP (0.44) | MEN1KMT2ABRD4RAB9ADRD2 | |
| SCHEMBL15506305 | 0.60 | MEN1 (0.46) | MEN1KMT2APRCPNPC1MAPT | |
| SCHEMBL20777507 | 0.59 | BCL2L1 (0.45) | CA1ALDH1A1HPGDDRD2DRD3 | |
| SCHEMBL29779937 | 0.59 | PRCP (0.55) | MEN1KMT2APRCPNPC1MAPT | |
| SCHEMBL4978935 | 0.59 | PRCP (0.55) | MEN1KMT2APRCPNPC1MAPT | |
| SCHEMBL20554529 | 0.58 | PTGS1 (0.56) | MEN1KMT2AMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039468-A1 | Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-02-14 | — | — | US | claimed |
| EP-1757592-A1 | NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2007-02-28 | — | — | EP | claimed |
| US-20080039468-A1 | Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-02-14 | — | — | US | disclosed |
| US-20080039468-A1 | Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-02-14 | — | — | US | disclosed |
| US-20080039468-A1 | Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-02-14 | — | — | US | disclosed |
| CN-1964953-A | Novel 3-phenyltetrahydrocinnolin-5-ol derivative and medical use thereof | NIPPON KAYAKU KK (JP) | 2007-05-16 | — | — | CN | disclosed |
| CN-1964953-A | Novel 3-phenyltetrahydrocinnolin-5-ol derivative and medical use thereof | NIPPON KAYAKU KK (JP) | 2007-05-16 | — | — | CN | disclosed |
| EP-1757592-A8 | NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1757592-A1 | NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2007-02-28 | — | — | EP | disclosed |
| EP-1757592-A1 | NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121105-A1 | NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039468-A1 | Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof | TPX2, HCCS, YWHAZ | SLC6A2 4826/4885SLC6A4 4710/4885SLC6A3 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.