Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930774 | 0.88 | CHRM4 (0.38) | SYKMAP3K12CHRM4KHK | |
| SCHEMBL4930783 | 0.88 | CHRM4 (0.38) | SYKMAP3K12CHRM4KHK | |
| SCHEMBL4923945 | 0.87 | SYK (0.44) | SYKMAP3K12MAPK1HSD17B10CHRM4 | |
| SCHEMBL3887559 | 0.81 | SYK (0.43) | SYKMAP3K12MAPK1HSD17B10CHRM4 | |
| SCHEMBL4926985 | 0.80 | HRH4 (0.44) | L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3879480 | 0.80 | SYK (0.42) | SYKMAP3K12MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL4929741 | 0.78 | SYK (0.41) | SYKMAP3K12MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL4930822 | 0.78 | HSD17B10 (0.44) | SYKMAP3K12MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL4930043 | 0.78 | KHK (0.46) | SYKMAP3K12MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL3879868 | 0.78 | TRPV1 (0.50) | SYKMAPK1HSD17B10KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | NEUROGEN CORPORATION | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | PIGO, GPR52, GPR88 | SYK 2136/4885MAP3K12 2454/4885MAPK1 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.