Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 4/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930043 | 0.83 | KHK (0.46) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4924961 | 0.80 | SCN9A (0.47) | HSD17B10MAPK1TACR1SLC6A4KCNH2 | |
| SCHEMBL908060 | 0.80 | EGLN2 (0.41) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4929523 | 0.79 | MAPK1 (0.40) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4929606 | 0.79 | HTR2B (0.46) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4923945 | 0.79 | SYK (0.44) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL3887559 | 0.78 | SYK (0.43) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4928254 | 0.78 | SYK (0.45) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL4929741 | 0.77 | SYK (0.41) | HSD17B10MAPK1SYKKHKMAP3K12 | |
| SCHEMBL3879480 | 0.77 | SYK (0.42) | HSD17B10MAPK1SYKKHKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | NEUROGEN CORPORATION | 2008-05-29 | — | — | US | disclosed |
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | NEUROGEN CORPORATION | 2008-05-29 | — | — | US | disclosed |
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | NEUROGEN CORPORATION | 2008-05-29 | — | — | US | disclosed |
| EP-1838703-A2 | HETEROARYL SUBSTITUTED PIPERAZINYL-PYRIDINE ANALOGUES | NEUROGEN CORPORATION (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006078992-A2 | HETEROARYL SUBSTITUTED PIPERAZINYL-PYRIDINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124384-A1 | Heteroaryl Substituted Piperazinyl-Pyridine Analogues | PIGO, GPR52, GPR88 | HSD17B10 3111/4885MAPK1 3040/4885SYK 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.