Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930159 | 0.87 | ROCK2 (0.56) | KIF11HDAC1CYP3A4CYP2C19FFAR1 | |
| SCHEMBL4149080 | 0.83 | AGER (0.44) | HDAC1CYP3A4CYP2C19FLT1KDR | |
| SCHEMBL4154749 | 0.83 | ROCK2 (0.51) | HDAC1DYRK1AFLT1KDRROCK2 | |
| SCHEMBL4932096 | 0.82 | KCNH2 (0.53) | DYRK1AKDRKCNH2ROCK2 | |
| SCHEMBL4149001 | 0.81 | MEN1 (0.48) | NAMPTDYRK1AKDRKCNH2ROCK2 | |
| SCHEMBL4930265 | 0.80 | CLK1 (0.49) | CLK1DYRK1AKCNH2ROCK2 | |
| SCHEMBL4148712 | 0.80 | ALPL (0.51) | HDAC1KDM1ACLK1DYRK1AKCNH2 | |
| SCHEMBL4160085 | 0.78 | DYRK1A (0.52) | CYP3A4CYP2C19FFAR1CLK1DYRK1A | |
| SCHEMBL4146600 | 0.77 | CCNT1 (0.43) | NAMPTDYRK1AKDRKCNH2ROCK2 | |
| SCHEMBL4928741 | 0.77 | KCNH2 (0.41) | NAMPTCLK1DYRK1AKCNH2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | KIF11 1290/4885HDAC1 1819/4885KDM1A 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.