Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641259 | 0.84 | DYRK1A (0.51) | DYRK1ABCDIN3DHTR1BRPS6KB1AURKA | |
| SCHEMBL16668989 | 0.80 | NAMPT (0.55) | DYRK1ABCDIN3DHTR1BRPS6KB1AURKA | |
| SCHEMBL30299180 | 0.80 | NAMPT (0.55) | DYRK1ABCDIN3DHTR1BRPS6KB1AURKA | |
| SCHEMBL4160102 | 0.80 | INSR (0.45) | FYNWNT3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4930158 | 0.76 | NPC1 (0.52) | FYN | |
| SCHEMBL4139536 | 0.76 | FYN (0.67) | DYRK1AFYNCLK4CYP1A2CYP3A4 | |
| SCHEMBL4160085 | 0.76 | DYRK1A (0.52) | DYRK1AFYNRPS6KB1CLK4CYP1A2 | |
| SCHEMBL4149001 | 0.76 | MEN1 (0.48) | DYRK1AFYNNAMPTCLK4ROCK2 | |
| SCHEMBL4149080 | 0.75 | AGER (0.44) | FYNCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4154749 | 0.75 | ROCK2 (0.51) | DYRK1ARPS6KB1CLK4ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | DYRK1A 210/4885FYN 27/4885BCDIN3D 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.