Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934508 | 0.90 | ACHE (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL20178650 | 0.88 | ACHE (0.54) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL30197112 | 0.87 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL845803 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL2759079 | 0.83 | MAPT (0.62) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL20178649 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3349545 | 0.80 | ACHE (0.47) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL2759073 | 0.80 | TP53 (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL2819895 | 0.80 | ACHE (0.51) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL13170391 | 0.79 | ACHE (0.48) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394828-B2 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-20080300236-A1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | CODD ELLEN | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300236-A1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | TRPV1, OPRL1, TRPV2 | ALDH1A1 1216/4885MEN1 4610/4885KMT2A 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.