Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 3/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838436 | 0.77 | DRD3 (0.44) | DRD3METAP2APAF1NPC1NSD2 | |
| SCHEMBL4922627 | 0.76 | DRD3 (0.63) | DRD3MAPTHTTKAT2BHRH3 | |
| SCHEMBL791880 | 0.75 | DRD3 (0.61) | DRD3APAF1NPC1NSD2MAPT | |
| SCHEMBL13589520 | 0.74 | KDM4E (0.50) | APAF1NSD2MAPTADRA1AADRA2A | |
| SCHEMBL11722763 | 0.73 | DRD3 (0.59) | DRD3APAF1NPC1NSD2MAPT | |
| SCHEMBL5770043 | 0.73 | DRD3 (0.59) | DRD3APAF1NPC1NSD2MAPT | |
| SCHEMBL4932077 | 0.73 | MEN1 (0.61) | DRD3APAF1NPC1NSD2MAPT | |
| SCHEMBL27619286 | 0.73 | L3MBTL1 (0.56) | METAP2APAF1MAPTRAB9ABLM | |
| SCHEMBL4930910 | 0.73 | ACHE (0.62) | DRD3SMN1; SMN2NPSR1HRH3MEN1 | |
| SCHEMBL5884397 | 0.72 | DRD3 (0.57) | DRD3APAF1NPC1NSD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | DRD3 2434/4885METAP2 4020/4885APAF1 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.