Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 14/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4933915 | 0.81 | TBK1 (0.41) | TBK1IKBKEALDH1A1HPGD | |
| SCHEMBL4931435 | 0.66 | ANO1 (0.40) | KDM4ENPC1RAB9APTPRC | |
| SCHEMBL2832149 | 0.66 | TBK1 (0.39) | TBK1IKBKE | |
| SCHEMBL29999252 | 0.65 | HSD17B10 (0.54) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL5555769 | 0.64 | KDM4E (0.51) | TBK1IKBKEKDM4EALDH1A1CYP2C9 | |
| SCHEMBL30482350 | 0.63 | TBK1 (0.48) | TBK1IKBKEMAPT | |
| SCHEMBL27041409 | 0.62 | TTR (0.48) | KDM4EALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL5431721 | 0.61 | TBK1 (0.46) | TBK1IKBKEKDM4E | |
| SCHEMBL6503762 | 0.60 | SHMT1 (0.56) | KDM4EALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL4924406 | 0.60 | HSPA5 (0.40) | SMN1; SMN2NPC1MAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167309-A1 | Pharmaceutical Compounds | ASTEX THERAPEUTICS, LTD. (UK) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167309-A1 | Pharmaceutical Compounds | CCNO, CDK2, CDK1 | TBK1 2327/4885IKBKE 89/4885KDM4E 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.