Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556366 | 0.87 | TBK1 (0.55) | KDM4ESMN1; SMN2TBK1GAAIKBKE | |
| SCHEMBL5555722 | 0.86 | MEN1 (0.49) | SMN1; SMN2TBK1IKBKEALDH1A1KMT2A | |
| SCHEMBL5554758 | 0.86 | TBK1 (0.56) | KDM4ERAB9ATBK1GAAIKBKE | |
| SCHEMBL5554860 | 0.83 | CHEK1 (0.52) | KDM4ESMN1; SMN2RAB9ANPC1TBK1 | |
| SCHEMBL6015302 | 0.82 | CHEK1 (0.49) | KDM4ETBK1KMT2AMAPTATM | |
| SCHEMBL2524367 | 0.80 | KDM4E (0.48) | KDM4ESMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL5192550 | 0.78 | KDM4E (0.55) | KDM4ESMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL6496085 | 0.75 | KDM4E (0.63) | KDM4ESMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL1564481 | 0.74 | CHEK1 (0.67) | — | |
| SCHEMBL5555715 | 0.74 | PIN1 (0.47) | TBK1XDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | KDM4E 713/4885SMN1; SMN2 4643/4885RAB9A 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.