Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 9/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930817 | 0.92 | PIM1 (0.53) | PRKCIPIM1PRKCZ | |
| SCHEMBL639635 | 0.80 | PRKCI (0.49) | PRKCIAXLPRKCZ | |
| SCHEMBL14416945 | 0.80 | PRKCI (0.49) | PRKCIAXLPRKCZ | |
| SCHEMBL639634 | 0.80 | PRKCI (0.49) | PRKCIAXLPRKCZ | |
| SCHEMBL15830444 | 0.77 | SYK (0.42) | AXL | |
| SCHEMBL21299954 | 0.77 | AXL (0.39) | PIM1AXL | |
| SCHEMBL23012617 | 0.75 | CHRNB2 (0.48) | PRKCIPIM1AXLPRKCZ | |
| SCHEMBL7098800 | 0.75 | CHRNB2 (0.48) | PRKCIPIM1AXLPRKCZ | |
| SCHEMBL23013465 | 0.75 | CHRNB2 (0.48) | PRKCIPIM1AXLPRKCZ | |
| SCHEMBL4925453 | 0.74 | ROCK2 (0.45) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | PRKCI 800/4885PIM1 1463/4885AXL 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.