SCHEMBL4932422 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	KMT2A	Q03164	5/20	0.73

▸	HDAC3	O15379	1/20	0.62

▸	HDAC4	P56524	1/20	0.62

▸	KCNH2	Q12809	1/20	0.62

▸	HDAC1	Q13547	1/20	0.62

▸	HDAC7	Q8WUI4	1/20	0.62

▸	HDAC2	Q92769	1/20	0.62

▸	HDAC10	Q969S8	1/20	0.62

▸	HDAC11	Q96DB2	1/20	0.62

▸	HDAC8	Q9BY41	1/20	0.62

▸	HDAC6	Q9UBN7	1/20	0.62

▸	HDAC9	Q9UKV0	1/20	0.62

▸	HDAC5	Q9UQL6	1/20	0.62

▸	MC5R	P33032	2/20	0.60

▸	MC3R	P41968	2/20	0.60

▸	MC1R	Q01726	2/20	0.60

▸	CDK2	P24941	1/20	0.60

▸	GPR84	Q9NQS5	1/20	0.59

▸	NPC1	O15118	1/20	0.57

▸	POLB	P06746	1/20	0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8998901	0.85	MAPT (0.64)	KMT2AGPR84POLBMEN1LMNA
SCHEMBL23745542	0.83	HTR2A (0.77)	KMT2AMC5RMC3RMC1RNPC1
SCHEMBL2884867	0.83	GPR84 (0.74)	KMT2ACDK2GPR84NPC1POLB
Hydrochloric Acid SCHEMBL23721903	0.82	HTR2A (0.76)	KMT2AMC5RMC3RMC1RNPC1
SCHEMBL211881	0.81	HDAC1 (0.77)	KMT2AHDAC3HDAC4KCNH2HDAC1
SCHEMBL29855629	0.81	HDAC1 (0.77)	KMT2AHDAC3HDAC4KCNH2HDAC1
SCHEMBL211880	0.81	HDAC1 (0.77)	KMT2AHDAC3HDAC4KCNH2HDAC1
SCHEMBL18088393	0.81	MC5R (0.71)	KMT2AHDAC3HDAC4KCNH2HDAC1
SCHEMBL830201	0.81	MC5R (0.79)	KMT2AHDAC3HDAC4KCNH2HDAC1
SCHEMBL13949803	0.81	HDAC1 (0.70)	KMT2AHDAC3HDAC4KCNH2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-10227295-B2	Selective histone deactylase 6 inhibitors	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2019-03-12	—	—	US	disclosed
US-9956192-B2	Selective histone deactylase 6 inhibitors	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2018-05-01	—	—	US	disclosed
US-20170369428-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.	2017-12-28	—	—	US	disclosed
US-9751832-B2	Selective histone deactylase 6 inhibitors	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2017-09-05	—	—	US	disclosed
US-20170035710-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.	2017-02-09	—	—	US	disclosed
US-9409858-B2	Selective histone deactylase 6 inhibitors	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2016-08-09	—	—	US	disclosed
US-20160185716-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS	2016-06-30	—	—	US	disclosed
US-20150056213-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT	2015-02-26	—	—	US	disclosed
WO-2015017546-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2015-02-05	—	—	WO	disclosed
EP-2822926-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	H. Lee Moffitt Cancer Center And Research Institute, Inc. (US)	2015-01-14	—	—	EP	disclosed
WO-2013134467-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US)	2013-09-12	—	—	WO	disclosed
US-20080070954-A1	Acylurea Connected And Sulfonylurea Connected Hydroxamates	S*BIO PTE LTD. (SG)	2008-03-20	—	—	US	disclosed
US-20080070954-A1	Acylurea Connected And Sulfonylurea Connected Hydroxamates	S*BIO PTE LTD. (SG)	2008-03-20	—	—	US	disclosed
US-20080070954-A1	Acylurea Connected And Sulfonylurea Connected Hydroxamates	S*BIO PTE LTD. (SG)	2008-03-20	—	—	US	disclosed
EP-1685094-A4	ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES	S BIO PTE LTD (SG)	2007-08-22	—	—	EP	disclosed
EP-1685094-A1	ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES	S*Bio Pte Ltd (SG)	2006-08-02	—	—	EP	disclosed
WO-2005040101-A1	ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES	S*BIO PTE LTD (SG)	2005-05-06	—	—	WO	disclosed
WO-2005040101-A1	ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES	S*BIO PTE LTD (SG)	2005-05-06	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20080070954-A1	Acylurea Connected And Sulfonylurea Connected Hydroxamates	HDAC1, HDAC3, HDAC4	KMT2A 105/4885HDAC3 2/4885HDAC4 3/4885
US-20160185716-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	HDAC1, HDAC6, HDAC2	KMT2A 53/4885HDAC3 9/4885HDAC4 10/4885
US-20150056213-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	HDAC1, HDAC5, HDAC11	KMT2A 44/4885HDAC3 9/4885HDAC4 8/4885
US-20170035710-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	HDAC1, HDAC5, HDAC11	KMT2A 44/4885HDAC3 9/4885HDAC4 8/4885
US-20170369428-A1	SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS	HDAC1, HDAC5, HDAC11	KMT2A 48/4885HDAC3 9/4885HDAC4 8/4885
US-10227295-B2	Selective histone deactylase 6 inhibitors	HDAC1, HDAC5, HDAC11	KMT2A 48/4885HDAC3 9/4885HDAC4 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.