Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847028 | 0.87 | MAPT (0.80) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7853851 | 0.86 | MAPT (0.66) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7838803 | 0.85 | LMNA (0.76) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL4932422 | 0.85 | KMT2A (0.73) | LMNAKMT2AMEN1POLBGPR84 | |
| SCHEMBL8998953 | 0.85 | EGFR (0.67) | MAPTALDH1A1EGFRSRCLMNA | |
| SCHEMBL7846817 | 0.83 | MAPT (0.78) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL8696236 | 0.83 | LMNA (0.66) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7850581 | 0.83 | KMT2A (0.65) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7852416 | 0.83 | MAPT (0.66) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2884867 | 0.82 | GPR84 (0.74) | MAPTKMT2AMEN1POLBGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |