Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 8/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930886 | 0.87 | ALDH1A1 (0.46) | GRIN2BCYP2D6CYP2C9CYP3A4MAPT | |
| SCHEMBL4933145 | 0.84 | GPR119 (0.51) | GRIN2BCYP2D6CYP2C9CYP3A4USP30 | |
| SCHEMBL20775269 | 0.84 | GRIN2B (0.66) | GRIN2BCYP2D6CYP2C9CYP3A4KDM4C | |
| SCHEMBL4930989 | 0.84 | MKNK1 (0.44) | MAPTGSK3BVCPKDM4CMKNK1 | |
| SCHEMBL4148646 | 0.80 | KDM4C (0.45) | MAPTGSK3BVCPKDM4CMKNK1 | |
| SCHEMBL4925453 | 0.78 | ROCK2 (0.45) | MAPTGSK3BMKNK1 | |
| SCHEMBL4930924 | 0.75 | CYP2C9 (0.50) | CYP2C9USP30 | |
| SCHEMBL3650096 | 0.74 | GRIN2B (0.56) | GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL15205760 | 0.74 | GRIN2B (0.42) | GRIN2BCYP2D6CYP2C9CYP3A4MAPT | |
| SCHEMBL14720234 | 0.72 | GRIN2B (0.64) | GRIN2BCYP2D6CYP2C9CYP3A4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | GALAPAGOS NV (BE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194584-A1 | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes | ROCK1, TNK2, GRK1 | GRIN2B 1201/4885CYP2D6 2175/4885CYP2C9 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.