Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.64 |
| ▸ | FADS1 | O60427 | 5/20 | 0.62 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.51 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127641 | 0.83 | AHR (0.58) | TNFEGFRKDM4EMEN1KMT2A | |
| SCHEMBL31098966 | 0.83 | TNF (0.57) | TNFEGFRABCG2PDE5AMEN1 | |
| SCHEMBL1921849 | 0.82 | ABCG2 (0.53) | EGFRABCG2PDE5AKDM4EROCK1 | |
| SCHEMBL20356686 | 0.82 | EGFR (0.61) | TNFEGFRABCG2KDM4EKMT2A | |
| SCHEMBL26789989 | 0.82 | TNF (0.64) | TNFEGFRABCG2 | |
| SCHEMBL4738590 | 0.81 | EGFR (0.64) | EGFRABCG2ERBB2PTK6 | |
| SCHEMBL4741370 | 0.81 | GRM4 (0.50) | TNFFADS1EGFRLCKABCG2 | |
| SCHEMBL3377751 | 0.81 | GRM4 (0.59) | TNFFADS1EGFRABCG2HTR3E | |
| SCHEMBL4741984 | 0.80 | EGFR (0.58) | TNFFADS1EGFRLCKABCG2 | |
| SCHEMBL31098967 | 0.78 | ABCG2 (0.64) | TNFEGFRABCG2PDE5AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | TNF 1/4885FADS1 1059/4885EGFR 1259/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | TNF 790/4885FADS1 270/4885EGFR 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.