SCHEMBL493520

SCHEMBL493520

O=C(O)CCCCCNC(=O)CI

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 1/20 0.63
ADRA1A P35348 1/20 0.59
MAPK1 P28482 1/20 0.56
EPHX2 P34913 6/20 0.51
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.50
NFKB1 P19838 1/20 0.50
PMP22 Q01453 1/20 0.50
PLA2G2A P14555 1/20 0.49
ITGB3 P05106 2/20 0.47
ITGA2B P08514 2/20 0.47
ALDH1A1 P00352 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1257927 1.00 PRMT1 (0.63) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL30905813 0.96 PRMT1 (0.59) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL1927840 0.87 ALDH1A1 (0.59) PRMT1MAPK1ALDH1A1SMN1; SMN2
SCHEMBL1927654 0.87 ALDH1A1 (0.59) PRMT1MAPK1ALDH1A1SMN1; SMN2
SCHEMBL24483715 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL11468363 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL8507619 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL17767810 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL22506195 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA
SCHEMBL8766995 0.85 PRMT1 (0.71) PRMT1ADRA1AMAPK1EPHX2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3148577-B1 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE BIOLOGICAL E LTD (IN) 2021-01-20 EP claimed
US-20170198004-A1 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE BIOLOGICAL E LTD (IN) 2017-07-13 US claimed
EP-3148577-A2 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE Biological E Limited (IN) 2017-04-05 EP claimed
WO-2015181834-A2 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE BIOLOGICAL E LIMITED (IN) 2015-12-03 WO claimed
EP-2478049-B1 A POLYMER SUPPORT UNIV CAPE TOWN (ZA) 2015-02-25 EP claimed
EP-2171457-B1 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES INNOVA BIOSCIENCES LTD (GB) 2013-07-10 EP claimed
EP-2488208-A1 COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF The Governors of the University of Alberta (CA) 2012-08-22 EP claimed
US-20110229510-A1 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2011-09-22 US claimed
EP-2315771-A2 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF Sloan Kettering Institute For Cancer Research (US) 2011-05-04 EP claimed
WO-2010006343-A2 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2010-01-14 WO claimed
EP-0996455-B1 ALPHA-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF SLOAN KETTERING INST CANCER (US) 2009-12-16 EP claimed
CN-118852478-A Sulfated glycosaminoglycan biomaterials as proteoglycan mimics 格莱克罗吉克斯公司 2024-10-29 CN disclosed
CN-118541159-A Methods of producing TIL products using PD-1 TALEN gene knockdown 艾欧凡斯生物治疗公司 2024-08-23 CN disclosed
CN-115697352-B Sulfated glycosaminoglycan biomaterials as proteoglycan mimics 格莱克罗吉克斯公司 2024-07-19 CN disclosed
US-20240238328-A1 Sulfated Glycosaminoglycan Biomaterials as Proteoglycan Mimics GLYCOLOGIX INC (US) 2024-07-18 US disclosed
EP-1091751-A1 TRIMERIC ANTIGENIC O-LINKED GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USES THEREOF Sloan-Kettering Institute For Cancer Research (US) 2001-04-18 EP disclosed
EP-0996455-A1 $g(a)-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF Sloan-Kettering Institute For Cancer Research (US) 2000-05-03 EP disclosed
WO-1999048515-A9 TRIMERIC ANTIGENIC O-LINKED GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USES THEREOF SLOAN KETTERING INST CANCER (US) 1999-11-25 WO disclosed
WO-1999048515-A1 TRIMERIC ANTIGENIC O-LINKED GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1999-09-30 WO disclosed
WO-1998046246-A1 α-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1998-10-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240238328-A1 Sulfated Glycosaminoglycan Biomaterials as Proteoglycan Mimics MATR3, CSGALNACT1, CD44 PRMT1 4313/4885ADRA1A 4832/4885MAPK1 4457/4885
US-20170198004-A1 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE STT3B, CD14, STT3A PRMT1 1013/4885ADRA1A 4865/4885MAPK1 4244/4885
US-20110229510-A1 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF B3GAT3, MICA, SIGLEC7 PRMT1 3624/4885ADRA1A 4846/4885MAPK1 4197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.