Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 4/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.39 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | PPARD | Q03181 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4936724 | 1.00 | MEN1 (0.45) | MEN1KMT2ACES2CES1GPR84 | |
| Bicarbonate SCHEMBL4938106 | 1.00 | MEN1 (0.45) | MEN1KMT2ACES2CES1GPR84 | |
| Bicarbonate SCHEMBL4931887 | 1.00 | MEN1 (0.45) | MEN1KMT2ACES2CES1GPR84 | |
| Bicarbonate SCHEMBL4935530 | 0.92 | ALDH1A1 (0.40) | MEN1KMT2ACES2CES1GPR84 | |
| SCHEMBL21523295 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR | |
| SCHEMBL21523293 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR | |
| SCHEMBL4934095 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR | |
| SCHEMBL20718552 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR | |
| SCHEMBL4931847 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR | |
| SCHEMBL4938498 | 0.92 | MEN1 (0.52) | MEN1KMT2ACES2CES1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130087072-A1 | Reversibly Switchable Surfactants and Methods of Use Thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2013-04-11 | — | — | US | disclosed |
| US-8283385-B2 | Emulsion polymerization; oil industry | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2012-10-09 | — | — | US | disclosed |
| US-20080197084-A1 | Reversibly switchable surfactants and methods of use thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-08-21 | — | — | US | disclosed |
| EP-1957434-A1 | REVERSIBLY SWITCHABLE SURFACTANTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007056859-A1 | REVERSIBLY SWITCHABLE SURFACTANTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080197084-A1 | Reversibly switchable surfactants and methods of use thereof | SGMS1, SGMS2, HDHD5 | MEN1 3941/4885KMT2A 3368/4885CES2 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.