Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 4/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525319 | 0.84 | KDM1A (0.55) | KDM1ABLMMEN1KMT2ACSNK2A2 | |
| SCHEMBL4363742 | 0.82 | MAPT (0.63) | DHODHKDRGRM4PDK1BLM | |
| SCHEMBL14069839 | 0.80 | MAPT (0.54) | DHODHKDRGRM4PDK1BLM | |
| SCHEMBL525630 | 0.79 | CFTR (0.54) | KDM1ACSNK2A1MEN1KMT2ACFTR | |
| SCHEMBL14070017 | 0.79 | DHODH (0.57) | DHODHKDRGRM4PDK1BLM | |
| SCHEMBL4931471 | 0.79 | DHODH (0.52) | DHODHKDRGRM4PDK1CSNK2A1 | |
| SCHEMBL21852321 | 0.79 | MEN1 (0.56) | DHODHKDM1AMEN1ALDH1A1KMT2A | |
| SCHEMBL14069875 | 0.78 | MAPT (0.53) | DHODHKDRGRM4PDK1BLM | |
| SCHEMBL14069855 | 0.78 | KCNJ5 (0.56) | DHODHKDRGRM4PDK1TRPV1 | |
| SCHEMBL5032528 | 0.78 | KDM1A (0.51) | GRM4KDM1ACSNK2A1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-09-11 | — | — | US | disclosed |
| WO-2007002461-A1 | 3,4-SUBSTITUTED THIAZOLES AS AMPK ACTIVATORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002461-A1 | 3,4-SUBSTITUTED THIAZOLES AS AMPK ACTIVATORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221088-A1 | 3,4-Substituted Thiazoles as Ampk Activators | PRKAG3, PRKAG1, PRKAG2 | DHODH 3268/4885KDR 2007/4885GRM4 1968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.