Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441052 | 0.87 | ALOX5 (0.60) | CFTRALOX5MAPTMAPK1LMNA | |
| SCHEMBL525812 | 0.84 | KDM1A (0.56) | ALOX5KDM1ANPY5RGAAMAPT | |
| SCHEMBL5034911 | 0.82 | ALOX5 (0.56) | ALOX5KDM1AGAAMAPTL3MBTL1 | |
| SCHEMBL525271 | 0.82 | KDM1A (0.54) | KDM1AGAAMAPTMAPK1L3MBTL1 | |
| SCHEMBL2285389 | 0.82 | AMY1A (0.60) | KDM1AGAAMAPTL3MBTL1POLB | |
| SCHEMBL525682 | 0.81 | KDM1A (0.76) | ALOX5KDM1AGAAMAPTMAPK1 | |
| SCHEMBL5200233 | 0.81 | MAPT (0.68) | ALOX5KDM1AGAAMAPTMAPK1 | |
| SCHEMBL4919827 | 0.81 | KDM1A (0.76) | KDM1AGAAMAPTMAPK1LMNA | |
| SCHEMBL5442823 | 0.80 | MAPT (0.50) | CFTRALOX5NPY5RGAAMAPT | |
| SCHEMBL3953547 | 0.80 | MAPT (0.65) | CFTRALOX5NPY5RGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513430-B2 | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-08-20 | — | — | US | claimed |
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | claimed |
| US-8513430-B2 | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120029029-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | US | disclosed |
| WO-2012015715-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| EP-1907369-A4 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | REDDYS LAB LTD DR (IN) | 2009-07-22 | — | — | EP | disclosed |
| CN-101273022-A | Thiazole derivatives as AMPK activators | REDDYS LAB LTD DR (IN) | 2008-09-24 | — | — | CN | disclosed |
| EP-1907369-A1 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | Dr. Reddy's Laboratories Ltd. (IN) | 2008-04-09 | — | — | EP | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| WO-2007005785-A1 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-11 | — | — | WO | disclosed |
| WO-2007005785-A1 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | PRKAG1, PRKAG2, PRKAB1 | CFTR 1209/4885ALOX5 3778/4885KDM1A 4356/4885 |
| US-20120029029-A1 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS | HSD11B1, HSD11B2, HSD3B1 | CFTR 934/4885ALOX5 516/4885KDM1A 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.