Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.47 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938222 | 0.89 | HPGD (0.61) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4946603 | 0.87 | HPGD (0.59) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28862183 | 0.85 | TP53 (0.62) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13668125 | 0.82 | DRD2 (0.48) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4942745 | 0.81 | PDE2A (0.47) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18969121 | 0.79 | KDM4E (0.73) | ALDH1A1SMN1; SMN2HPGDKMT2ATP53 | |
| SCHEMBL4944430 | 0.78 | TP53 (0.60) | DRD2DRD3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28261635 | 0.77 | ALDH1A1 (0.72) | DRD2ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4944395 | 0.76 | LMNA (0.54) | ALDH1A1SMN1; SMN2HPGDKMT2ATP53 | |
| SCHEMBL29076120 | 0.75 | KDM4E (0.77) | ALDH1A1SMN1; SMN2HPGDKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2008-11-27 | — | — | US | disclosed |
| EP-1773774-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014918-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIK2 | DRD2 299/4885DRD3 574/4885ALDH1A1 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.