Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628173 | 0.98 | — | — | |
| SCHEMBL25286708 | 0.86 | FDPS (0.40) | FDPSCYP2C19SLC6A3CHRM2CHRM1 | |
| SCHEMBL8671012 | 0.78 | FDPS (0.47) | FDPSCYP2C19SLC6A3CHRM2CHRM1 | |
| SCHEMBL10860666 | 0.78 | — | — | |
| SCHEMBL9441399 | 0.78 | — | — | |
| SCHEMBL1998111 | 0.77 | DRD4 (0.41) | FDPSCYP2C19SLC6A3CHRM2CHRM1 | |
| SCHEMBL247632 | 0.77 | — | — | |
| SCHEMBL6997367 | 0.76 | FDPS (0.38) | FDPSCYP2C19SLC6A3CHRM2CHRM1 | |
| SCHEMBL2000599 | 0.74 | DRD4 (0.38) | FDPSCYP2C19SLC6A3CHRM2CHRM1 | |
| SCHEMBL841788 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293931-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | LOS ALAMOS NATIONAL SECURITY, LLC | 2008-11-27 | — | — | US | disclosed |
| US-20070065841-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | ENERGY, U.S. DEPARTMENT OF | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293931-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | POLRMT, FBL, POLL | SLC6A3 2974/4885CHRM2 4129/4885CHRM3 3144/4885 |
| US-20070065841-A1 | Methods and compositions for the removal of nucleic acid amplification inhibitors | POLRMT, FBL, POLL | SLC6A3 2974/4885CHRM2 4129/4885CHRM3 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.