Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 5/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.48 |
| ▸ | INSR | P06213 | 4/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940389 | 0.89 | NEK1 (0.45) | PLAUPLATKDM4EALDH1A1CYP3A4 | |
| SCHEMBL4934472 | 0.89 | PRKCI (0.48) | CHUKCAMKK2INSRMAPK8PRKCI | |
| SCHEMBL14027958 | 0.84 | CHUK (0.57) | CHUKCAMKK2INSRMAPK8PRKCI | |
| Hydrochloric Acid SCHEMBL4938858 | 0.84 | CHUK (0.56) | CHUKCAMKK2INSRMAPK8PRKCI | |
| SCHEMBL4934713 | 0.81 | NEK1 (0.48) | KDM4EALDH1A1MAPK14NEK1NPC1 | |
| SCHEMBL4937700 | 0.81 | CDK8 (0.47) | KDM4EALDH1A1MAPK14PKN1PKN2 | |
| SCHEMBL1838448 | 0.81 | MKNK2 (0.58) | CHUKCAMKK2INSRMAPK8PRKCI | |
| SCHEMBL4933913 | 0.80 | RAB9A (0.47) | KDM4EALDH1A1MAPK14NPC1PKM | |
| SCHEMBL14027963 | 0.80 | RIPK1 (0.49) | CHUKCAMKK2INSRMAPK8CYP3A4 | |
| Hydrochloric Acid SCHEMBL4940884 | 0.80 | RIPK1 (0.48) | CHUKCAMKK2INSRMAPK8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255085-A1 | Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255085-A1 | Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders | GSK3B, GSK3A, PYGB | CHUK 90/4885CAMKK2 201/4885INSR 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.