Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 5/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493258 | 0.94 | EPHX2 (0.44) | EPHX2GAAHTTFPR2PROKR1 | |
| SCHEMBL493683 | 0.94 | EPHX2 (0.39) | EPHX2BDKRB1GAAHTTKMT2A | |
| SCHEMBL493742 | 0.93 | KMT2A (0.40) | EPHX2BDKRB1KMT2AMEN1 | |
| SCHEMBL494263 | 0.92 | EPHX2 (0.46) | EPHX2GAAFPR2PROKR1 | |
| SCHEMBL492466 | 0.88 | EPHX2 (0.37) | EPHX2BDKRB1KMT2AMEN1 | |
| SCHEMBL493594 | 0.88 | EPHX2 (0.43) | EPHX2KMT2AMEN1 | |
| SCHEMBL493146 | 0.88 | EPHX2 (0.48) | EPHX2GAAKMT2AMEN1FPR2 | |
| SCHEMBL492606 | 0.87 | EPHX2 (0.41) | EPHX2KMT2A | |
| SCHEMBL493124 | 0.87 | MEN1 (0.41) | GAAHTTKMT2AMEN1 | |
| SCHEMBL493421 | 0.87 | EPHX2 (0.46) | EPHX2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | EPHX2 2567/4885BDKRB1 1622/4885GAA 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.