Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.49 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.49 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946103 | 0.82 | HPGD (0.56) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4939480 | 0.81 | HPGD (0.52) | HPGDKCNQ3KCNQ2ALDH1A1LMNA | |
| SCHEMBL4938496 | 0.79 | HPGD (0.58) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4938487 | 0.79 | HPGD (0.54) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4944587 | 0.78 | HPGD (0.57) | HPGDKCNQ3KCNQ2ALDH1A1LMNA | |
| SCHEMBL19700160 | 0.78 | KCNQ3 (0.61) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL19690597 | 0.77 | HPGD (0.52) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4943406 | 0.77 | HPGD (0.52) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4946187 | 0.76 | HPGD (0.51) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL22299355 | 0.76 | KCNQ3 (0.62) | HPGDKCNQ3KCNQ2KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | claimed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | KCNQ1, KCNQ2, KCNA1 | HPGD 2327/4885KCNQ3 8/4885KCNQ2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.