SCHEMBL4943638

SCHEMBL4943638

COc1ccc(OC)c(-c2ccc(C(=O)N=C(N)N)o2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 18/20 1.00
ALDH1A1 P00352 1/20 0.67
MAPT P10636 1/20 0.67
HPGD P15428 1/20 0.67
S1PR4 O95977 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4537678 0.86 SLC9A1 (1.00) SLC9A1ALDH1A1HPGD
SCHEMBL4940241 0.86 SLC9A1 (1.00) SLC9A1
SCHEMBL4941063 0.86 SLC9A1 (1.00) SLC9A1
SCHEMBL4943003 0.80 ALDH1A1 (0.76) SLC9A1ALDH1A1MAPTHPGDS1PR4
SCHEMBL4943634 0.78 ALDH1A1 (0.64) SLC9A1ALDH1A1MAPTHPGDS1PR4
SCHEMBL4943767 0.77 SLC9A1 (0.79) SLC9A1
SCHEMBL27873986 0.77 ALDH1A1 (0.71) SLC9A1ALDH1A1MAPTHPGDS1PR4
SCHEMBL4948239 0.76 SLC9A1 (0.73) SLC9A1
SCHEMBL4943685 0.75 SLC9A1 (1.00) SLC9A1ALDH1A1HPGD
SCHEMBL4943380 0.75 SLC9A1 (1.00) SLC9A1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7351843-B2 Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2008-04-01 US claimed
US-20070299131-A1 Furancarbonylguanidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-12-27 US claimed
US-7351843-B2 Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2008-04-01 US disclosed
US-20070299131-A1 Furancarbonylguanidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070299131-A1 Furancarbonylguanidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them SLC9A1, NHERF1, SLC5A1 SLC9A1 1/4885ALDH1A1 297/4885MAPT 4846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.