Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | AGXT | P21549 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9080783 | 0.98 | AGXT (0.50) | IDO1AGXTTSHRCA1CA2 | |
| SCHEMBL28489986 | 0.84 | IDO1 (0.50) | IDO1AGXTAOC3MAOBRAB9A | |
| SCHEMBL5700743 | 0.76 | ALDH1A1 (0.33) | IDO1AOC3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11386184 | 0.76 | TP53 (0.41) | TSHRAOC3MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28812595 | 0.74 | LMNA (0.38) | TSHRAOC3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL21484985 | 0.74 | TSHR (0.46) | IDO1AGXTTSHRAOC3MAPT | |
| SCHEMBL1577188 | 0.74 | TSHR (0.46) | IDO1AGXTTSHRCA1CA2 | |
| SCHEMBL5310161 | 0.72 | TSHR (0.44) | IDO1AGXTTSHRAOC3GAA | |
| SCHEMBL10872451 | 0.72 | BCHE (0.42) | IDO1TSHRMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7667460 | 0.71 | ALDH1A1 (0.47) | CA1CA2CA9MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108997242-B | Substituted phenyl pyrazolone derivative, preparation and application | 浙江大学 | 2020-10-20 | — | — | CN | claimed |
| CN-108997242-A | Substituted phenyl pyrazole quinoline ketone derivatives and preparation and application | 浙江大学 | 2018-12-14 | — | — | CN | claimed |
| CN-113336704-B | Danshensu derivative and preparation method and medical application thereof | 上海大学 | 2022-10-11 | — | — | CN | disclosed |
| EP-3864013-A1 | THYROID HORMONE RECEPTOR AGONISTS | InventisBio Co., Ltd. (CN) | 2021-08-18 | — | — | EP | disclosed |
| CN-108997242-B | Substituted phenyl pyrazolone derivative, preparation and application | 浙江大学 | 2020-10-20 | — | — | CN | disclosed |
| CN-108997242-B | Substituted phenyl pyrazolone derivative, preparation and application | 浙江大学 | 2020-10-20 | — | — | CN | disclosed |
| CN-108997242-A | Substituted phenyl pyrazole quinoline ketone derivatives and preparation and application | 浙江大学 | 2018-12-14 | — | — | CN | disclosed |
| CN-108997242-A | Substituted phenyl pyrazole quinoline ketone derivatives and preparation and application | 浙江大学 | 2018-12-14 | — | — | CN | disclosed |
| CN-1724519-B | Indole kind compound with insuline sensitizing activity and its preparation method and use | GUIYANG MEDICAL COLLEGE | 2012-06-27 | — | — | CN | disclosed |
| US-20080227790-A1 | Pyridazinone Derivatives and their Use as Pde4 Inhibitors | ALTANA PHARMA AG (DE) | 2008-09-18 | — | — | US | disclosed |
| EP-1716123-A1 | PYRIDAZINONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| CN-1724519-A | Indole kind compound with insuline sensitizing activity and its preparation method and use | GUIYANG MEDICAL COLLEGE (CN) | 2006-01-25 | — | — | CN | disclosed |
| WO-2005075437-A1 | PYRIDAZINONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227790-A1 | Pyridazinone Derivatives and their Use as Pde4 Inhibitors | PDE4A, PDE4B, PDE5A | IDO1 1879/4885AGXT 3055/4885TSHR 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.