Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276146 | 0.90 | PDE4B (0.42) | PDE4BSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL4949413 | 0.85 | PDE4B (0.52) | PDE4BSMN1; SMN2PKMALDH1A1 | |
| SCHEMBL4948891 | 0.84 | PDE4B (0.52) | PDE4BCSF1RSYKALDH1A1MAPT | |
| SCHEMBL4949429 | 0.79 | PDE4B (0.50) | PDE4BSMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL13593041 | 0.77 | PDE4B (0.48) | PDE4BCSF1RSYK | |
| SCHEMBL2478982 | 0.76 | PDE4B (0.45) | PDE4BCSF1RSYK | |
| SCHEMBL2479653 | 0.75 | PDE4B (0.60) | PDE4BSMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2501627 | 0.74 | PDE4B (0.63) | PDE4BCSF1RSYKALDH1A1 | |
| SCHEMBL4948734 | 0.73 | PDE4B (0.54) | PDE4B | |
| SCHEMBL4952539 | 0.72 | PDE4B (0.59) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |