Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275597 | 0.90 | PDE4B (0.53) | PDE4BPKMSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4946724 | 0.89 | PDE4B (0.56) | PDE4BCYP3A4CYP2C9 | |
| SCHEMBL4949413 | 0.82 | PDE4B (0.52) | PDE4BPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL4948891 | 0.81 | PDE4B (0.52) | PDE4BALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL4949101 | 0.81 | PDE4B (0.68) | PDE4B | |
| SCHEMBL4628322 | 0.80 | PDE4B (0.57) | PDE4BSMN1; SMN2ATMMAPTCYP3A4 | |
| SCHEMBL8312156 | 0.80 | PDE4B (0.57) | PDE4B | |
| SCHEMBL4625986 | 0.79 | PDE4B (0.55) | PDE4BHTR4 | |
| SCHEMBL1275608 | 0.79 | PDE4B (0.59) | PDE4BCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL4264207 | 0.79 | PDE4B (0.57) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |