Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479653 | 0.90 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL4948891 | 0.88 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL4952539 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4944370 | 0.85 | PDE4B (0.38) | PDE4BALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4949429 | 0.82 | PDE4B (0.50) | PDE4BALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4949426 | 0.81 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2501627 | 0.78 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL2481592 | 0.77 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4948739 | 0.76 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4946547 | 0.76 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |