SCHEMBL4944697

SCHEMBL4944697

CCCCCc1c(CCCCC)c2cc3nc(cc4ccc(cc5nc(cc1[nH]2)C=C5)[nH]4)C=C3

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 1/20 0.34
▸ GPR84 Q9NQS5 5/20 0.34
▸ HSD17B10 Q99714 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ HPGD P15428 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ XBP1 P17861 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ PTGS2 P35354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3720964 0.94 KCNH2 (0.34) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL28019877 0.85 STAT3 (0.43) GPR84HSD17B10KDM4EALDH1A1HPGD
SCHEMBL5133634 0.85 STAT3 (0.42) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL6003904 0.84 STAT3 (0.41) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL15510967 0.84 STAT3 (0.41) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL3520094 0.84 STAT3 (0.41) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL3522373 0.84 STAT3 (0.41) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL7647119 0.84 STAT3 (0.41) KCNH2GPR84HSD17B10KDM4EALDH1A1
SCHEMBL7256360 0.83 — —
SCHEMBL4944703 0.83 STAT3 (0.40) KCNH2GPR84HSD17B10KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230257500-A1 RADICALLY POLYMERIZABLE COMPOSITIONS BNY MELLON CORPORATE TRUSTEE SERVICES LIMITED, AS SECURITY AGENT (GB) 2023-08-17 — — US disclosed
US-11518834-B2 Radically polymerizable compositions Polynt Composites USA, Inc. (US) 2022-12-06 — — US disclosed
EP-3906265-A1 RADICALLY POLYMERIZABLE COMPOSITIONS Polynt Composites USA Inc. (US) 2021-11-10 — — EP disclosed
CN-113474383-A Radically polymerizable composition 波林复合材料美国股份有限公司 2021-10-01 — — CN disclosed
WO-2020142632-A1 RADICALLY POLYMERIZABLE COMPOSITIONS Polynt Composites USA, Inc. (US) 2020-07-09 — — WO disclosed
US-20200207895-A1 RADICALLY POLYMERIZABLE COMPOSITIONS BNY MELLON CORPORATE TRUSTEE SERVICES LIMITED, AS SECURITY AGENT (GB) 2020-07-02 — — US disclosed
US-10696863-B2 Additives for curable liquid compositions DURA CHEMICALS, INC. (US) 2020-06-30 — — US disclosed
US-20180291233-A1 Additives for Curable Liquid Compositions DURA CHEMICALS, INC. 2018-10-11 — — US disclosed
US-20180265470-A1 Drier Composition and Use Thereof PPG EUROPE B V (NL) 2018-09-20 — — US disclosed
US-9976054-B2 Additives for curable liquid compositions DURA CHEMICALS, INC. (US) 2018-05-22 — — US disclosed
WO-2012092034-A2 ADDITIVES FOR CURABLE LIQUID COMPOSITIONS DURA CHEMICALS, INC. (US) 2012-07-05 — — WO disclosed
US-20120165435-A1 ADDITIVES FOR CURABLE LIQUID COMPOSITIONS DURA CHEMICALS, INC. 2012-06-28 — — US disclosed
US-20080119504-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY AXON BIOCHEMICALS B.V. (NL) 2008-05-22 — — US disclosed
US-7332503-B2 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2008-02-19 — — US disclosed
US-7238705-B2 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2007-07-03 — — US disclosed
US-20050143408-A1 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2005-06-30 — — US disclosed
US-20040018956-A1 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2004-01-29 — — US disclosed
EP-1309553-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY Axon Biochemicals B.V. (NL) 2003-05-14 — — EP disclosed
WO-2002014279-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY AXON BIOCHEMICALS B.V. (NL) 2002-02-21 — — WO disclosed
WO-1995029914-A1 A METHOD OF SYNTHESIZING 5,15-DIARYLBENZOCHLORIN-7-ONE COMPOUNDS THE UNIVERSITY OF BRITISH COLUMBIA (CA) 1995-11-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050143408-A1 Aporphine esters and their use in therapy PRLHR, LPXN, NPSR1 KCNH2 2353/4885GPR84 752/4885HSD17B10 398/4885
US-20180265470-A1 Drier Composition and Use Thereof DCTD, AP3D1, TET2 KCNH2 885/4885GPR84 1818/4885HSD17B10 3484/4885
US-20040018956-A1 Aporphine esters and their use in therapy PRLHR, LPXN, NPSR1 KCNH2 2353/4885GPR84 752/4885HSD17B10 398/4885
US-20080119504-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY PRLHR, LPXN, HTR1A KCNH2 2323/4885GPR84 756/4885HSD17B10 433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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