SCHEMBL4944703

SCHEMBL4944703

CCCCCc1c2nc(c(CCCCC)c3ccc(cc4nc(cc5ccc1[nH]5)C=C4)[nH]3)C=C2

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.40
▸ STAT1 P42224 1/20 0.40
▸ MAPT P10636 2/20 0.33
▸ HTT P42858 2/20 0.33
▸ SIRT1 Q96EB6 1/20 0.32
▸ HSD17B10 Q99714 3/20 0.32
▸ LMNA P02545 1/20 0.32
▸ XBP1 P17861 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ KDM4E B2RXH2 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ HPGD P15428 2/20 0.32
▸ GAA P10253 1/20 0.32
▸ GPR84 Q9NQS5 2/20 0.31
▸ KCNH2 Q12809 1/20 0.31
▸ PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29910098 0.99 STAT3 (0.39) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL5133634 0.96 STAT3 (0.42) STAT3STAT1MAPTHTTSIRT1
SCHEMBL4551743 0.96 STAT3 (0.44) STAT3STAT1MAPTHTTSIRT1
SCHEMBL3720959 0.95 STAT3 (0.37) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL6003904 0.95 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL3522373 0.95 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL3520094 0.95 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL15510967 0.95 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL7647119 0.95 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL17419215 0.95 STAT3 (0.43) STAT3STAT1MAPTHTTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230257500-A1 RADICALLY POLYMERIZABLE COMPOSITIONS BNY MELLON CORPORATE TRUSTEE SERVICES LIMITED, AS SECURITY AGENT (GB) 2023-08-17 — — US disclosed
US-11518834-B2 Radically polymerizable compositions Polynt Composites USA, Inc. (US) 2022-12-06 — — US disclosed
EP-3906265-A1 RADICALLY POLYMERIZABLE COMPOSITIONS Polynt Composites USA Inc. (US) 2021-11-10 — — EP disclosed
CN-113474383-A Radically polymerizable composition 波林复合材料美国股份有限公司 2021-10-01 — — CN disclosed
WO-2020142632-A1 RADICALLY POLYMERIZABLE COMPOSITIONS Polynt Composites USA, Inc. (US) 2020-07-09 — — WO disclosed
US-20200207895-A1 RADICALLY POLYMERIZABLE COMPOSITIONS BNY MELLON CORPORATE TRUSTEE SERVICES LIMITED, AS SECURITY AGENT (GB) 2020-07-02 — — US disclosed
US-10696863-B2 Additives for curable liquid compositions DURA CHEMICALS, INC. (US) 2020-06-30 — — US disclosed
US-20180291233-A1 Additives for Curable Liquid Compositions DURA CHEMICALS, INC. 2018-10-11 — — US disclosed
US-20180265470-A1 Drier Composition and Use Thereof PPG EUROPE B V (NL) 2018-09-20 — — US disclosed
US-9976054-B2 Additives for curable liquid compositions DURA CHEMICALS, INC. (US) 2018-05-22 — — US disclosed
WO-2012092034-A2 ADDITIVES FOR CURABLE LIQUID COMPOSITIONS DURA CHEMICALS, INC. (US) 2012-07-05 — — WO disclosed
US-20120165435-A1 ADDITIVES FOR CURABLE LIQUID COMPOSITIONS DURA CHEMICALS, INC. 2012-06-28 — — US disclosed
US-20080119504-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY AXON BIOCHEMICALS B.V. (NL) 2008-05-22 — — US disclosed
US-7332503-B2 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2008-02-19 — — US disclosed
US-7238705-B2 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2007-07-03 — — US disclosed
US-20050143408-A1 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2005-06-30 — — US disclosed
US-20040018956-A1 Aporphine esters and their use in therapy AXON BIOCHEMICALS B.V. (NL) 2004-01-29 — — US disclosed
EP-1309553-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY Axon Biochemicals B.V. (NL) 2003-05-14 — — EP disclosed
WO-2002014279-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY AXON BIOCHEMICALS B.V. (NL) 2002-02-21 — — WO disclosed
WO-1995029914-A1 A METHOD OF SYNTHESIZING 5,15-DIARYLBENZOCHLORIN-7-ONE COMPOUNDS THE UNIVERSITY OF BRITISH COLUMBIA (CA) 1995-11-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050143408-A1 Aporphine esters and their use in therapy PRLHR, LPXN, NPSR1 STAT3 3999/4885STAT1 3802/4885MAPT 1857/4885
US-20180265470-A1 Drier Composition and Use Thereof DCTD, AP3D1, TET2 STAT3 4191/4885STAT1 4549/4885MAPT 1001/4885
US-20040018956-A1 Aporphine esters and their use in therapy PRLHR, LPXN, NPSR1 STAT3 3999/4885STAT1 3802/4885MAPT 1857/4885
US-20080119504-A1 NEW APORPHINE ESTERS AND THEIR USE IN THERAPY PRLHR, LPXN, HTR1A STAT3 4158/4885STAT1 3938/4885MAPT 1801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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