SCHEMBL5133634

SCHEMBL5133634

CCCCCc1c2nc(cc3ccc(cc4nc(cc5ccc1[nH]5)C=C4)[nH]3)C=C2

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.42
▸ STAT1 P42224 1/20 0.42
▸ MAPT P10636 2/20 0.32
▸ HTT P42858 2/20 0.32
▸ SIRT1 Q96EB6 1/20 0.32
▸ HSD17B10 Q99714 3/20 0.31
▸ LMNA P02545 1/20 0.31
▸ XBP1 P17861 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ ALDH1A1 P00352 2/20 0.31
▸ HPGD P15428 2/20 0.31
▸ GAA P10253 1/20 0.31
▸ GPR84 Q9NQS5 2/20 0.31
▸ PTGS2 P35354 1/20 0.30
▸ KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7647119 0.99 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL6003904 0.99 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL3520094 0.99 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL15510967 0.99 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL3522373 0.99 STAT3 (0.41) STAT3STAT1MAPTHTTHSD17B10
Hydrochloric Acid SCHEMBL27872840 0.97 STAT3 (0.40) STAT3STAT1MAPTHTTHSD17B10
SCHEMBL4551743 0.97 STAT3 (0.44) STAT3STAT1MAPTHTTSIRT1
SCHEMBL3527775 0.96 STAT3 (0.43) STAT3STAT1MAPTHTTSIRT1
SCHEMBL4944703 0.96 STAT3 (0.40) STAT3STAT1MAPTHTTSIRT1
SCHEMBL17419215 0.96 STAT3 (0.43) STAT3STAT1MAPTHTTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109824679-A A kind of preparation method of substituted aryl porphyrin 中国科学院长春应用化学研究所 2019-05-31 — — CN claimed
WO-1991019978-A1 USING 5,10,15,20-TETRAKIS(4-CARBOXYPHENYL)PORPHINE FOR DETECTING AND TREATING LUNG CANCERS ST. MARY'S HOSPITAL AND MEDICAL CENTER, INC. (US) 1991-12-26 — — WO claimed
JP-2291602-A — — None — — JP disclosed
US-20230302144-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer ONCOSELECT THERAPEUTICS, LLC (US) 2023-09-28 — — US disclosed
US-11590233-B2 Porphyrin compounds and compositions useful for treating cancer ONCOSELECT THERAPEUTICS, LLC (US) 2023-02-28 — — US disclosed
CN-109922834-B Porphyrin compounds and compositions for the treatment of cancer 良药治疗公司 2022-09-23 — — CN disclosed
EP-4000675-A1 METHOD FOR OBTAINING FUNCTIONALIZED POLYMERIC SURFACES WITH PHOTOSENSITIZERS, FUNCTIONALIZED POLYMERIC MATERIAL AND USE THEREOF Universidade de São Paulo - USP (BR) 2022-05-25 — — EP disclosed
CN-114126695-A Method for obtaining functionalized polymer surfaces with photosensitizers, functionalized polymer materials and uses thereof 巴西圣保罗大学 2022-03-01 — — CN disclosed
US-20190184021-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer ONCOSELECT THERAPEUTICS, LLC 2019-06-20 — — US disclosed
CN-109824679-A A kind of preparation method of substituted aryl porphyrin 中国科学院长春应用化学研究所 2019-05-31 — — CN disclosed
CN-109824679-A A kind of preparation method of substituted aryl porphyrin 中国科学院长春应用化学研究所 2019-05-31 — — CN disclosed
US-5345008-A Decomposition of organic hydroperoxides with nitrated porphyrin complexes SUN COMPANY, INC. (R&M) (US) 1994-09-06 — — US disclosed
EP-0527623-A2 Allylic oxidation of olefins SUN COMPANY, INC. (R&M) (US) 1993-02-17 — — EP disclosed
EP-0522841-A2 Decomposition of organic hydroperoxides SUN COMPANY, INC. (R&M) (US) 1993-01-13 — — EP disclosed
US-5120886-A Contacting with substituted metal complex catalyst SUN REFINING AND MARKETING COMPANY (US) 1992-06-09 — — US disclosed
EP-0471561-A2 Metal coordination complex catalysts containing a halogenated ligand for hydrocarbon oxidation Sun Refining and Marketing Company (US) 1992-02-19 — — EP disclosed
EP-0427472-A2 Chromium halogenated coordination complexes for the oxidation of butane to methylethylketone SUN REFINING AND MARKETING COMPANY (US) 1991-05-15 — — EP disclosed
JP-H02291602-A METAL PORPHYRIN POLYMER FILM SERVING AS CONDUCTOR FOR ELECTRIC CATALYST IDAHO RES FOUND INC 1990-12-03 — — JP disclosed
US-4970348-A Chromium halogenated coordination complexes for the oxidation of butane to methylethylketone SUN REFINING AND MARKETING COMPANY (US) 1990-11-13 — — US disclosed
EP-0376689-A2 Polymeric films of metalloporphyrins as conductive materials for electrocatalysis IDAHO RESEARCH FOUNDATION, INC. (US) 1990-07-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230302144-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer KIT, HCCS, PPIF STAT3 1427/4885STAT1 4192/4885MAPT 3494/4885
US-11590233-B2 Porphyrin compounds and compositions useful for treating cancer KIT, HCCS, PPIF STAT3 1427/4885STAT1 4192/4885MAPT 3494/4885
US-20190184021-A1 Porphyrin Compounds and Compositions Useful for Treating Cancer TK2, KIT, HCCS STAT3 923/4885STAT1 3508/4885MAPT 3539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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