Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 5/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949101 | 0.88 | PDE4B (0.68) | PDE4BMTNR1BTHRBCSF1R | |
| SCHEMBL1276130 | 0.88 | PDE4B (0.62) | PDE4BMTNR1BTHRBCSF1R | |
| SCHEMBL4949711 | 0.84 | PDE4B (0.64) | PDE4BMTNR1BCSF1RALDH1A1LMNA | |
| SCHEMBL4952737 | 0.84 | PDE4B (0.61) | PDE4BTHRBCSF1R | |
| SCHEMBL4628322 | 0.82 | PDE4B (0.57) | PDE4BMTNR1BCSF1RCYP3A4CYP2C9 | |
| SCHEMBL4949741 | 0.81 | PDE4B (0.60) | PDE4BCSF1R | |
| SCHEMBL4625986 | 0.80 | PDE4B (0.55) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4949173 | 0.80 | PDE4B (0.69) | PDE4BMTNR1BCSF1R | |
| SCHEMBL4951313 | 0.80 | PDE4B (0.65) | PDE4BMTNR1BCSF1RMEN1ALDH1A1 | |
| SCHEMBL4950089 | 0.80 | PDE4B (0.67) | PDE4BMTNR1BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |