Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284014 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTHPGDMEN1KMT2A | |
| SCHEMBL23518433 | 0.79 | SMN1; SMN2 (0.86) | SMN1; SMN2HTTHPGDMEN1KMT2A | |
| SCHEMBL30205881 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTHPGDMEN1KMT2A | |
| SCHEMBL25243087 | 0.78 | HDAC3 (0.53) | SMN1; SMN2HTTHPGDMEN1KMT2A | |
| SCHEMBL19897705 | 0.78 | HDAC3 (0.52) | SMN1; SMN2KMT2AHDAC1HDAC2HDAC3 | |
| SCHEMBL17495017 | 0.78 | NPC1 (0.46) | SMN1; SMN2HTTMEN1KMT2AHDAC1 | |
| SCHEMBL265392 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL16197391 | 0.76 | HDAC3 (0.57) | SMN1; SMN2MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL4938509 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTHPGDMEN1KMT2A | |
| SCHEMBL31451422 | 0.75 | L3MBTL1 (0.49) | SMN1; SMN2HTTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | KCNQ1, KCNQ2, KCNA1 | SMN1; SMN2 3418/4885HTT 3396/4885HPGD 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.