Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191996 | 0.97 | ACHE (0.59) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| Hydrochloric Acid SCHEMBL4381078 | 0.95 | ACHE (0.56) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL909800 | 0.86 | ACHE (0.48) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| Alcohol SCHEMBL9525249 | 0.86 | PTGS2 (0.54) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL21264353 | 0.85 | MAPT (0.47) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL2529901 | 0.85 | ACHE (0.46) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| Hydrochloric Acid SCHEMBL8521226 | 0.83 | MAPT (0.46) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL12903992 | 0.83 | ACHE (0.44) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL6977792 | 0.83 | ACHE (0.50) | ACHEMAPTCYP3A4CA9CYP19A1 | |
| SCHEMBL191032 | 0.81 | TPMT (0.53) | ACHEMAPTCYP3A4CA9CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7074789-B2 | Kinase inhibitors | AMGEN INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040116388-A1 | triazine compoound inhibitors of enzymes that catalyze phosphoryl transfer and/or that bind ATP/GTP nucleotides | AMGEN INC. | 2004-06-17 | — | — | US | disclosed |
| EP-1218360-A1 | TRIAZINE KINASE INHIBITORS | Amgen Inc., (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025220-A1 | TRIAZINE KINASE INHIBITORS | AMGEN INC. (US) | 2001-04-12 | — | — | WO | disclosed |