Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL6157198 | 0.89 | SLC7A5 (0.35) | SLC7A5 | |
| Tyrosine SCHEMBL4948067 | 0.89 | SLC7A5 (0.35) | SLC7A5 | |
| Phenylalanine SCHEMBL10428796 | 0.88 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL10428795 | 0.88 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL25286397 | 0.86 | SLC7A5 (0.60) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28558704 | 0.85 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28912532 | 0.85 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL4947368 | 0.85 | SLC7A5 (0.39) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL27553494 | 0.84 | SLC7A5 (0.40) | SLC7A5ERAP2ERAP1 | |
| Tyrosine SCHEMBL27792454 | 0.84 | SLC7A5 (0.57) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1769066-A4 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA FARBER CANCER INST INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1769066-A2 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA-FARBER CANCER INSTITUTE (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2005113589-A2 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA-FARBER CANCER INSTITUTE (US) | 2005-12-01 | — | — | WO | disclosed |