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Tyrosine

Tyrosine

SCHEMBL4948067

NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.35
▸ ITGA4 P13612 4/20 0.35
▸ CTSC P53634 1/20 0.33
▸ OPRM1 P35372 3/20 0.33
▸ OPRD1 P41143 3/20 0.33
▸ OPRK1 P41145 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL6157198 1.00 SLC7A5 (0.35) SLC7A5ITGA4CTSCOPRM1OPRD1
Tyrosine SCHEMBL7630915 0.95 SLC7A5 (0.39) SLC7A5ITGA4
Tyrosine SCHEMBL6554685 0.92 ITGA4 (0.33) SLC7A5ITGA4
Tyrosine SCHEMBL6511987 0.90 SLC7A5 (0.36) SLC7A5ITGA4
Tyrosine SCHEMBL8185595 0.89 F2 (0.35) —
Tyrosine SCHEMBL4947371 0.89 SLC7A5 (0.44) SLC7A5
Dl-Phenylalanine SCHEMBL29201498 0.88 ALPI (0.41) SLC7A5ITGA4CTSC
Tyrosine SCHEMBL6554735 0.88 SLC7A5 (0.39) SLC7A5ITGA4
Tyrosine SCHEMBL4948058 0.88 ITGA4 (0.32) SLC7A5ITGA4
Tyrosine SCHEMBL6157195 0.86 TYR (0.33) SLC7A5ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1769066-A4 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2008-08-13 — — EP disclosed
EP-1769066-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2007-04-04 — — EP disclosed
WO-2005113589-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2005-12-01 — — WO disclosed
EP-1458241-A4 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2005-11-09 — — EP disclosed
US-20050003484-A1 Modified antigen-presenting cells DANA FARBER CANCER INSTITUTE 2005-01-06 — — US disclosed
EP-1458241-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2004-09-22 — — EP disclosed
WO-2003065977-A9 MODIFIED ANTIGEN-PRESENTING CELLS DANA FARBER CANCER INST INC (US) 2003-10-16 — — WO disclosed
WO-2003065977-A2 MODIFIED ANTIGEN-PRESENTING CELLS DANA-FARBER CANCER INSTITUTE (US) 2003-08-14 — — WO disclosed