Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL6157195 | 0.88 | TYR (0.33) | SLC7A5TYR | |
| Tyrosine SCHEMBL4948058 | 0.86 | ITGA4 (0.32) | SLC7A5TYR | |
| Tyrosine SCHEMBL4947371 | 0.85 | SLC7A5 (0.44) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL25286397 | 0.80 | SLC7A5 (0.60) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL10428796 | 0.80 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL10428795 | 0.80 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| Glycine SCHEMBL3967554 | 0.79 | SLC1A5 (0.35) | SLC7A5IDO1ITGB3ITGA2B | |
| Dl-Phenylalanine SCHEMBL28912532 | 0.79 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL3155213 | 0.78 | ALPI (0.46) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL9978767 | 0.78 | SLC7A5 (0.46) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1769066-A4 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA FARBER CANCER INST INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1769066-A2 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA-FARBER CANCER INSTITUTE (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2005113589-A2 | MODIFIED ANTIGEN-PRESENTING CELLS | DANA-FARBER CANCER INSTITUTE (US) | 2005-12-01 | — | — | WO | disclosed |