Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946209 | 0.88 | PLA2G2A (0.47) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL1996313 | 0.85 | ALDH1A1 (0.52) | MAPTMAPK1PLA2G2A | |
| SCHEMBL4892207 | 0.77 | PLA2G2A (0.58) | MAPTELANEF2PLAUCTRB1 | |
| SCHEMBL4884093 | 0.77 | AR (0.58) | MAPTELANEPLA2G2A | |
| SCHEMBL4893680 | 0.77 | AR (0.60) | MAPTELANEPLA2G2A | |
| SCHEMBL31219110 | 0.75 | PLA2G2A (0.52) | MAPTMAPK1PLA2G2A | |
| SCHEMBL12228538 | 0.75 | ALDH1A1 (0.49) | MAPTELANEMAPK1 | |
| SCHEMBL9400620 | 0.74 | MAPT (0.60) | MAPTELANEF2PLAUCTRB1 | |
| SCHEMBL6858317 | 0.73 | ELANE (0.51) | MAPTELANEF2PLAUCTRB1 | |
| SCHEMBL6091749 | 0.73 | MAPT (0.47) | MAPTELANEMAPK1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2003129-B1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-08-09 | — | — | EP | disclosed |
| EP-2003129-B1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-08-09 | — | — | EP | disclosed |
| EP-2003129-A1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |
| EP-2003129-A1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |