Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4948035 | 0.88 | MAPT (0.52) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL4946256 | 0.78 | PIK3R1 (0.37) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL4946246 | 0.78 | PIK3R1 (0.37) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL4946248 | 0.78 | PIK3R1 (0.37) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL6306900 | 0.78 | CCR2 (0.71) | CCR2 | |
| SCHEMBL13993110 | 0.75 | PLA2G2A (0.37) | PLA2G2APIK3R1PIK3CA | |
| SCHEMBL1996313 | 0.72 | ALDH1A1 (0.52) | PLA2G2ACCR2 | |
| SCHEMBL30965369 | 0.71 | AR (0.42) | PLA2G2A | |
| SCHEMBL1163283 | 0.70 | CNR2 (0.56) | PIK3R1PIK3CA | |
| SCHEMBL3652866 | 0.70 | PIK3R1 (0.50) | PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2003129-B1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-08-09 | — | — | EP | disclosed |
| EP-2003129-B1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-08-09 | — | — | EP | disclosed |
| EP-2003129-A1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |
| EP-2003129-A1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |