Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089267 | 0.92 | LMNA (0.38) | LMNAPGK1EGLN1ALDH1A1MAPT | |
| SCHEMBL4946449 | 0.83 | KDM4E (0.31) | ALDH1A1MAPTNPC1RAB9AHPGD | |
| SCHEMBL4091251 | 0.74 | AURKA (0.35) | MAPTNPC1RAB9A | |
| SCHEMBL482970 | 0.73 | BACE1 (0.35) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL18459405 | 0.72 | BRD4 (0.42) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3100964 | 0.72 | ALDH1A1 (0.38) | LMNAALDH1A1MAPTHPGDCYP1A2 | |
| SCHEMBL481938 | 0.72 | — | — | |
| SCHEMBL27851953 | 0.70 | L3MBTL1 (0.35) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL30628499 | 0.69 | MAPT (0.36) | LMNAALDH1A1MAPTMETHPGD | |
| SCHEMBL26632138 | 0.69 | MAPT (0.34) | LMNAALDH1A1MAPTMETHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885362-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127458-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |