Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12396113 | 0.79 | TMIGD3 (0.41) | PDGFRACCNE1CDK2ADORA2ATMIGD3 | |
| SCHEMBL215612 | 0.73 | CDK1 (0.57) | CCNE1CDK2FGFR1SLC22A6CDK1 | |
| SCHEMBL4948978 | 0.69 | CYP1A2 (0.49) | ADORA2AADORA2BCYP1A2KMT2ATHPO | |
| SCHEMBL4948967 | 0.69 | CYP1A2 (0.49) | ADORA2AADORA2BCYP1A2KMT2ATHPO | |
| SCHEMBL2160243 | 0.68 | FGFR1 (0.47) | PDGFRACCNE1CDK2ADORA2ATMIGD3 | |
| SCHEMBL8154514 | 0.67 | ADORA2A (0.43) | ADORA2ATMIGD3ADORA1ADORA2BCYP1A2 | |
| SCHEMBL4949185 | 0.67 | CYP1A2 (0.47) | PDGFRACCNE1CDK2ADORA2AADORA2B | |
| SCHEMBL4949178 | 0.67 | CYP1A2 (0.47) | PDGFRACCNE1CDK2ADORA2AADORA2B | |
| SCHEMBL7209426 | 0.67 | PDE4A (0.60) | PDGFRACCNE1CDK2ADORA2ATMIGD3 | |
| SCHEMBL382916 | 0.67 | FGFR1 (0.66) | ADORA2AADORA1ADORA2BFGFR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | disclosed |