Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.46 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARD | Q03181 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6833060 | 0.94 | TSHR (0.56) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL7260179 | 0.87 | TSHR (0.60) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL29116301 | 0.87 | TSHR (0.60) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL29060484 | 0.85 | PHF8 (0.46) | TSHRLMNAALDH1A1SLC22A6OR51E2 | |
| SCHEMBL27451286 | 0.84 | LMNA (0.58) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL10455169 | 0.84 | TSHR (0.46) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL10456017 | 0.84 | TSHR (0.46) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL9276995 | 0.83 | DGKA (0.55) | TSHRLMNAALDH1A1GPR84PPARG | |
| SCHEMBL11132190 | 0.83 | TSHR (0.55) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL28242013 | 0.83 | TSHR (0.55) | TSHRLMNANFKB1PMP22ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8617605-B2 | Polymer release system | EGALET LTD. (GB) | 2013-12-31 | — | — | US | claimed |
| US-20080254122-A1 | Polymer release system | EGALET A/S | 2008-10-16 | — | — | US | claimed |
| US-20080254123-A1 | controll release opioid composition by erosion in aqueous solution; preventing the side effect of immediate release opioid in blood stream; water soluble and water insoluble celluloses; pain treatment; polyethylene glycol, polypropylene glycol, copolymer of ethylene glycol and propylene glycol | EGALET A/S | 2008-10-16 | — | — | US | claimed |
| US-20040234602-A1 | Polymer release system | EGALET LTD. (GB) | 2004-11-25 | — | — | US | claimed |
| EP-1429739-A1 | POLYMER RELEASE SYSTEM | Egalet A/S (DK) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024429-A1 | POLYMER RELEASE SYSTEM | EGALET A/S (DK) | 2003-03-27 | — | — | WO | claimed |
| EP-2957281-A1 | POLYMER RELEASE SYSTEM | Egalet Ltd. (GB) | 2015-12-23 | — | — | EP | disclosed |